Keith A A Fox, Saverio Virdone, Karen S Pieper, Jean-Pierre Bassand, A John Camm, David A Fitzmaurice, Samuel Z Goldhaber, Shinya Goto, Sylvia Haas, Gloria Kayani, Ali Oto, Frank Misselwitz, Jonathan P Piccini, Frederik Dalgaard, Alexander G G Turpie, Freek W A Verheugt, Ajay K Kakkar, for the GARFIELD-AF Investigators.

European Heart Journal

GARFIELD-AF Risk Score For Mortality, Stroke, and Bleeding Within 2 Years in Patients With Atrial Fibrillation 10.1093/ehjqcco/qcab028

PJ Devereaux, MD, PhD, Andre Lamy, MD, Matthew TV Chan, MB, BS, PhD, René V. Allard, MD, Vladimir V. Lomivorotov, MD, PhD, Giovanni Landoni, MD, Hong Zheng, PhD, Domenico Paparella, MD, Michael H. McGillion, RN, PhD, Emilie P. Belley-Côté, MD, PhD, Joel L. Parlow, MD, Malcolm J. Underwood, MD, et al., for the VISION Cardiac Surgery Investigators†.

The New England Journal of Medicine (NEJM)

High-Sensitivity Troponin I After Cardiac Surgery and 30-Day Mortality 10.1056/NEJMoa2000803

Michael Walsh, Claudette Bethune, Andrew Smyth, Jessica Tyrwhitt, Shiangtung W. Jung, Rosie Z. Yu, Yanfeng Wang, Richard S. Geary, Jeffrey Weitz, Sanjay Bhanot, on Behalf of theCS4 Investigators

Clinical Research

Phase 2 Study of the Factor XI Antisense Inhibitor IONIS-FXIRx in Patients With ESRD 10.1016/j.ekir.2021.11.011

Thirunavukkarasu Sathish, Prof. Koon K Teo, Prof. Philip Britz-McKibbin, Biban Gill, Shofiqul Islam, Prof. Guillaume Paré, et al.

The Lancet

Variations In Risks From Smoking Between High-Income, Middle-Income, and Low-Income Countries: An Analysis of Data From 179 000 Participants From 63 Countries 10.1016/S2214-109X(21)00509-X

Paul F. Lebeau, Jae Hyun Byun, Khrystyna Platko, Paul Saliba, Matthew Sguazzin, Melissa E. MacDonald, Guillaume Paré, Gregory R. Steinberg, Luke J. Janssen, Suleiman A. Igdoura, Mark A. Tarnopolsky, S. R. Wayne Chen, Nabil G. Seidah, Jakob Magolan and Richard C. Austin.

Nature Communications

Caffeine Blocks SREBP2-Induced Hepatic PCSK9 Expression To Enhance LDLR-Mediated Cholesterol Clearance 10.1038/s41467-022-28240-9

Patricia Hewston, Courtney Kennedy, George Ioannidis, Dafna Merom, Genevieve Hladysh, Sharon Marr, Justin Lee, Richard Sztramko, Laurel Trainor, Amanda Grenier, Matthew Harold Woolhouse, Christopher Patterson and Alexandra Papaioannou.

BioMed Central (BMC)

Development of GERAS DANcing for Cognition and Exercise (DANCE): a feasibility study 10.1186/s40814-021-00956-3

Mukul Sharma, Eric E. Smith, Lesly A. Pearce, Ashkan Shoamanesh, Kanjana S. Perera, Shelagh B. Coutts, Dorte Damgaard, Sebastian F. Ameriso, Joung-Ho Rha, Boris Modrau, Byung-Woo Yoon, Marina Romano, Steven R. Messé, Jessica Barlinn, Johann Lambeck, Feryal Saad, Scott D. Berkowitz, Hardi Mundl, Stuart J. Connolly and Robert G. Hart and on behalf of the NAVIGATE ESUS MIND MRI Substudy Investigators

Stroke

Frequency and Patterns of Brain Infarction in Patients With Embolic Stroke of Undetermined Source: NAVIGATE ESUS Trial 10.1161/STROKEAHA.120.032976

Ali Zhang, Jessica A. Breznik, Rumi Clare,  Ishac Nazy,  Matthew S. Miller,  Dawn ME Bowdish,  Andrew P. Costa

medRxiv

Antibody Responses to 3rd Dose mRNA Vaccines in Nursing Home and Assisted Living Residents 10.1101/2021.12.17.21267996

Sharon Yeunga, Mark Rosenbergb, Donna Banach, Lisa Mayottee, Sonia S. Anand, Lac La Ronge Indian Band, Fort McKay First Nation, Heather Castleden

SSM – Population Health

Bonding social capital and health within four First Nations communities in Canada: A cross-sectional study 10.1016/j.ssmph.2021.100962

Allison E. Kennedy, Laura Cook, Jessica A. Breznik, Braeden Cowbrough, Jessica G. Wallace, Angela Huynh, James W. Smith, Kiho Son, Hannah Stacey, Jann Ang, Allison McGeer, Brenda L. Coleman, Maggie Larché, Mark Larché, Nathan Hambly, Parameswaran Nair, Kjetil Ask, Matthew S. Miller, Jonathan Bramson, Megan K. Levings, Ishac Nazy, Sarah Svenningsen, Manali Mukherjee, Dawn M. E. Bowdish

Viruses

Lasting Changes to Circulating Leukocytes in People with Mild SARS-CoV-2 Infections 10.3390/v13112239

RECOVERY Collaborative Group

COVID-19

Aspirin in Patients Admitted to Hospital with COVID-19 (RECOVERY): A Randomised, Controlled, Open-Label, Platform Trial 10.1016/S0140-6736(21)01825-0

Seung Mi Yoo, Vivan W C Lau, Craig Aarts, Bojana Bojovic, Gregory Steinberg, Joanne A Hammill, Anna Dvorkin-Gheva, Raja Ghosh, Jonathan L Bramson

OncoImmunology

Manufacturing T Cells in Hollow Fiber Membrane Bioreactors Changes Their Programming and Enhances Their Potency 10.1080/2162402X.2021.1995168

Matthew Sibbald, Natalia Pinilla-Echeverri, Mognee Alameer, Jorge Chavarria, Gustavo Dutra, Tej Sheth

COVID-19

Using Optical Coherence Tomography to Identify Lipid and Its Impact on Interventions and Clinical Events – A Scoping Review 10.1253/circj.CJ-21-0377

Alyson Takaoka, Benjamin Tam, Meredith Vanstone, France J. Clarke, Neala Hoad, Marilyn Swinton, Feli Toledo, Anne Boyle, Anne Woods, Erick H. Duan, Diane Heels-Ansdell, Lily Waugh, Mark Soth, Jill Rudkowski, Waleed Alhazzani, Dan Perri, Tania Ligori, Roman Jaeschke, Nicole Zytaruk & Deborah J. Cook.

BMC Health Services Research

Scale-up and Sustainability of a Personalized End-of-Life Care Intervention: A Longitudinal Mixed-Methods Study 10.1186/s12913-021-06241-6#Sec19

Arian Ghassemian, Jane Jiyoon Park, Michael W. Tsoulis & Harold Kim.

Allergy, Asthma & Clinical Immunology

Targeting the IL-5 Pathway in Eosinophilic Asthma: A Comparison of Mepolizumab to Benralizumab in the Reduction of Peripheral Eosinophil Counts 10.1186/s13223-020-00507-0

Netusha Thevaranjan, Alicja Puchta, Christian Schulz, Avee Naidoo, JC Szamosi, Chris P. Verschoor, Dessi Loukov, Louis P. Schenck, Jennifer Jury, Kevin P. Foley, Jonathan D. Schertzer, Maggie J. Larché, Donald J. Davidson, Elena F. Verdú, Michael G. Surette, Dawn ME Bowdish.

Cell Host & Microbe

Age-Associated Microbial Dysbiosis Promotes Intestinal Permeability, Systemic Inflammation and Macrophage Dysfunction 10.1016/j.chom.2017.03.002

Philippe Bégin, Jeannie Callum, Donald M. Arnold, et al.

Trials

Convalescent plasma for adults with acute COVID-19 respiratory illness (CONCOR-1): Study protocol for an international, multicentre, randomized, open-label trial 10.1186/s13063-021-05235-3

Tao Chen, Amy Po Yu Tsai, Seo Am Hur, Alyson W. Wong, Mohsen Sadatsafavi, Jolene H. Fisher, Kerri A. Johannson, Deborah Assayag, Julie Morisset, Shane Shapera, Nasreen Khalil, Charlene D. Fell, Helene Manganas, Gerard Cox, Teresa To, Andrea S. Gershon, Nathan Hambly, Andrew J. Halayko, Pearce G. Wilcox, Martin Kolb & Christopher J. Ryerson

Respiratory Research

Validation and minimum important difference of the UCSD Shortness of Breath Questionnaire in fibrotic interstitial lung disease 10.1186/s12931-021-01790-0

Paul Oykhman, Fernando Aleman Paramo, Prof Jean Bousquet, David W. Kennedy, Romina Brignardello-Petersen, Derek K. Chu

Allergy & Clinical Immunology

Comparative Efficacy and Safety of Monoclonal Antibodies and Aspirin Desensitization for Chronic Rhinosinusitis with Nasal Polyposis: A Systematic Review and Network Meta-Analysis: 10.1016/j.jaci.2021.09.009

Philippe Bégin, Jeannie Callum, Donald M. Arnold

Nature Medicine

Convalescent plasma for hospitalized patients with COVID-19: an open-label, randomized controlled trial: 10.1038/s41591-021-01488-2

Teresa M. Chan, Brandon Ruan, Daniel Lu, Mark Lee, Yusuf Yilmaz

Academic medicine

Systems to support scholarly social media: A qualitative exploration of enablers and barriers to new scholarship in academic medicine 10.36834/cmej.72490

P. Joseph, G. Roshandel, P. Gao, P. Pais, E. Lonn, D. Xavier, A. Avezum, J. Zhu, L. Liu, K. Sliwa, H. Gamra, S. Bangdiwala, K. Teo, R. Diaz, A. Dans, P. Lopez-Jaramillo, D. Prabhakaran, J M. Castellano, V.Fuster, A. Rodgers, M. Huffman, J. Bosch, G. Dagenais, R. Malekzadeh, S. Yusuf

Cardiovascular disease

Fixed-dose combination therapies with and without aspirin for primary prevention of cardiovascular disease: an individual participant data meta-analysis 10.1016/S0140-6736(21)01827-4

S. Shah, A. Tepler, C. Chung, G. Suarez, R. Peek Jr, A. Hung, C. Roumie, N. Narula

American Gastroenterological Association (AGA)

Host genetic determinants associated with Helicobacter pylori eradication treatment failure: A systematic review and meta-analysis 10.1053/j.gastro.2021.07.043.

N. Narula, E. Wong, M. Dehghan, A. Mente, S. Rangarajan, F. Lanas, P. Lopez-Jaramillo, P. Rohatgi, P. Lakshmi, R. Varma, A. Orlandini, A. Avezum, A. Wielgosz, P. Poirier, M. Almadi, Y. Altuntas, K. Keat Ng, J. Chifamba, K. Yeates, T. Puoane, R. Khatib, R. Yusuf, K. Boström, K. Zatonska, R. Iqbal, L. Weida, Z. Yibing, L. Sidong, A. Dans, A. Yusufali, N. Mohammadifard, J. Marshall, P. Moayyedi, W. Reinisch, S. Yusuf

BJM

Association of ultra-processed food intake with risk of inflammatory bowel disease: prospective cohort study 10.1136/bmj.n1554

V. Goel, D. Bulir, E. De Prophetis, M. Jamil, L. Rosella, D. Mertz, C. Regehr, M. Smieja

BJM

COVID-19 International Border Surveillance at Toronto’s Pearson Airport: A Cohort Study 10.1136/bmjopen-2021-050714

R. Whitlock, E. Belley-Cote, D. Paparella, J. Healey, K.Brady, M. Sharma, W. Reents, P. Budera, A. Baddour, P. Fila, P.J. Devereaux, A. Bogachev-Prokophiev, A. Boening, K. Teoh, G. Tagarakis, M. Slaughter, A. Royse, S. McGuinness, M. Alings, P. Punjabi, C. D. Mazer, R. Folkeringa, A. Colli, Á. Avezum, J. Nakamya, K. Balasubramanian, J. Vincent, P. Voisine, A. Lamy, S. Yusuf, S. Connolly

NEJM

Left Atrial Appendage Occlusion during Cardiac Surgery to Prevent Stroke  10.1056/NEJMoa2101897

D. Conen, M. Wang, PJ Devereaux, R. Whitlock, W. McIntyre, J. Healey, F. Yuan, S. Yusuf, A. Lamy

Journal of the American Heart Association (JAHA)

New-Onset Perioperative Atrial Fibrillation After Coronary Artery Bypass Grafting and Long-Term Risk of Adverse Events: An Analysis From the CORONARY Trial 10.1161/JAHA.120.020426

A. Bourguignon, D. Arnold, T. Warkentin, J. Smith, T. Pannu, J. Shrum, Z. Al Maqrashi, A. Shroff, M. Lessard, N. Blais, J.Kelton and I.Nazy

NEJM

Adjunct Immune Globulin for Vaccine-Induced Thrombotic Thrombocytopenia
10.1056/NEJMoa2107051

G. Juneja, M. Castelo, C. Yeh, S. Cerroni, B. Hansen, J. Chessum, J. Abraham, E. Cani, D. Dwivedi, D. Fraser, M. Slessarev, C. Martin, S. McGilvray, P. Gross, P. Liaw, J. Weitz, P. Kim

Journal of Thrombosis and Haemostasis (JTH)

Biomarkers of coagulation, endothelial function, and fibrinolysis in critically ill patients with COVID-19: A single-center prospective longitudinal study   10.1111/jth.15327

A. Shoaib, H. Van Spall, J. Wu, J. Cleland, T. McDonagh, M. Rashid, M. Mohamed, F. Ahmed, J. Deanfield, M. de Belder, C. Gale, M. Mamas

European Heart Journal (EHJ)

Substantial decline in hospital admissions for heart failure accompanied by increased community mortality during COVID-19 pandemic  10.1093/ehjqcco/qcab040