Education and Professional Standing

MD, University of Western Ontario, 1990
FRCPC Internal Medicine, 1994
FRCPC Hematology, 1995
MSc Health Research Methodology, 1998
Fellow of the Royal Society of Canada (FRSC), 2017

Dr Crowther has more than 400 peer reviewed publications, was inducted into the Royal Society of Canada in 2017, and received the 2017 International Society of Thrombosis and Haemostasis BACH Investigator Recognition Award. He was one of 14 scientists from the Michael G. DeGroote School of Medicine at McMaster University cited by Clarivate Analytics on its Highly Cited Researchers list (formerly known as Thomson Reuter’s annual publication of The World’s Most Influential Scientific Minds).

[View Dr. Crowther’s citations on PubMed]

Research Interests: Exploring ways of improving the way that we use our current anticoagulant drugs, including exploring established and novel interventions to mitigate bleeding and anticoagulant drugs in high-risk patient populations; Developing systematic reviews of key questions in hematology and thrombosis and basing guidelines on those reviews.

Education and Professional Standing

MD, University of Western Ontario, 1990
FRCPC Internal Medicine, 1994
FRCPC Hematology, 1995
MSc Health Research Methodology, 1998
Fellow of the Royal Society of Canada (FRSC), 2017

Dr Crowther has more than 400 peer reviewed publications, was inducted into the Royal Society of Canada in 2017, and received the 2017 International Society of Thrombosis and Haemostasis BACH Investigator Recognition Award. He was one of 14 scientists from the Michael G. DeGroote School of Medicine at McMaster University cited by Clarivate Analytics on its Highly Cited Researchers list (formerly known as Thomson Reuter’s annual publication of The World’s Most Influential Scientific Minds).

[View Dr. Crowther’s citations on PubMed]

Research Interests: Exploring ways of improving the way that we use our current anticoagulant drugs, including exploring established and novel interventions to mitigate bleeding and anticoagulant drugs in high-risk patient populations; Developing systematic reviews of key questions in hematology and thrombosis and basing guidelines on those reviews.

Dr. Weitz is Professor of Medicine and Biochemistry and Biomedical Sciences at McMaster University and Executive Director of the Thrombosis and Atherosclerosis Research Institute. Board Certified in Internal Medicine, Hematology and Medical Oncology, Dr. Weitz focuses his clinical practice on patients with thrombotic disorders. His research spans the spectrum from basic studies in the biochemistry of blood coagulation and fibrinolysis to animal models of thrombosis and on to clinical trials of antithrombotic therapy. The breadth of his work is highlighted by his over 500 publications in journals as diverse as the Journal of Clinical Investigation, Journal of Biological Chemistry, Biochemistry, Circulation, Blood, Annals of Internal Medicine, New England Journal of Medicine and Lancet, and 60 book chapters. The recipient of numerous awards, Dr. Weitz is a Fellow of the American Heart Association, the Royal Society of Canada and the Canadian Academy of Health Sciences.

By focusing on the basic mechanisms by which anticoagulants (blood thinners) and thrombolytic agents (clot digesting drugs) work, Dr. Weitz has opened new avenues of investigation. His demonstration that thrombin bound to fibrin is resistant to inactivation by available anticoagulants stimulated the development of new drugs, some of which are already being used in clinical practice. Through other research, Dr. Weitz has provided an explanation for the puzzling clinical observation that the clot digesting drug, tissue-type plasminogen activator or t-PA, produces more bleeding than was originally anticipated. This work has paved the way for new drugs that may be safer than t-PA.

Dr. Weitz is involved in clinical trials examining optimal methods for prevention, diagnosis and treatment of clotting disorders. He also is an active participant in the education of medical students, residents, and postdoctoral fellows. In addition, he coordinates a graduate course in medical sciences and his laboratory is a fertile training ground for graduate students and postdoctoral fellows in medical sciences and bioengineering.

Dr. Weitz is Professor of Medicine and Biochemistry and Biomedical Sciences at McMaster University and Executive Director of the Thrombosis and Atherosclerosis Research Institute. Board Certified in Internal Medicine, Hematology and Medical Oncology, Dr. Weitz focuses his clinical practice on patients with thrombotic disorders. His research spans the spectrum from basic studies in the biochemistry of blood coagulation and fibrinolysis to animal models of thrombosis and on to clinical trials of antithrombotic therapy. The breadth of his work is highlighted by his over 500 publications in journals as diverse as the Journal of Clinical Investigation, Journal of Biological Chemistry, Biochemistry, Circulation, Blood, Annals of Internal Medicine, New England Journal of Medicine and Lancet, and 60 book chapters. The recipient of numerous awards, Dr. Weitz is a Fellow of the American Heart Association, the Royal Society of Canada and the Canadian Academy of Health Sciences.

By focusing on the basic mechanisms by which anticoagulants (blood thinners) and thrombolytic agents (clot digesting drugs) work, Dr. Weitz has opened new avenues of investigation. His demonstration that thrombin bound to fibrin is resistant to inactivation by available anticoagulants stimulated the development of new drugs, some of which are already being used in clinical practice. Through other research, Dr. Weitz has provided an explanation for the puzzling clinical observation that the clot digesting drug, tissue-type plasminogen activator or t-PA, produces more bleeding than was originally anticipated. This work has paved the way for new drugs that may be safer than t-PA.

Dr. Weitz is involved in clinical trials examining optimal methods for prevention, diagnosis and treatment of clotting disorders. He also is an active participant in the education of medical students, residents, and postdoctoral fellows. In addition, he coordinates a graduate course in medical sciences and his laboratory is a fertile training ground for graduate students and postdoctoral fellows in medical sciences and bioengineering.

Associate Chair, Equity and Diversity, Department of Medicine

Director, Population Genomics Program, Department of Clinical Epidemiology and Biostatistics

Canada Research Chair in Ethnic Diversity and Cardiovascular Disease

Heart and Stroke Foundation / Michael G. DeGroote Chair in Population Health Research McMaster University

McMaster University’s Dr. Sonia Anand was only 33 years old when she landed the Eli Lilly Canada-May Cohen Chair in Women’s Health. Although her present research involves the environmental and genetic determinants of vascular and peripheral vascular disease in populations of varying ancestral origin, she is most recognized for her research on women’s health issues, particularly in the area of cardiovascular disease. The care and treatment of women’s cardiovascular disease, unique in its latent and non-specific symptoms, must differ from the standard employed for men to be successful, and Dr. Anand’s research is innovative in making this a priority.

As a Professor with the Department of Medicine and a member of the Leadership Council of the Heart and Stroke Foundation of Canada’s Heart Truth campaign, Dr. Anand has helped give women the tools they need to reduce their risk of cardiovascular disease. Studying the differences associated with each gender’s symptomatic experience of heart disease, Dr. Anand aims to clarify the way in which social factors interact with biological factors to impact cardiovascular health.

Dr. Anand is also the Principal Investigator of two large genetic association studies, including the CIHR/HSFO funded EPiDREAM study of 22,000 people from 21 countries. Complementing this research, Dr. Anand teaches clinical epidemiology courses in methodology and cardiovascular disease at McMaster University with the hope of influencing future generations of doctors to be mindful of women’s health matters.

Selected Publications

• Do R, Xie C, Zhang X, Islam S, Bailey S, Rangarajan S, McQueen M, Diaz R, Lisheng L, Wang X, Yusuf S, Engert J, Anand SS. Dietary Intake Modifies the Effect of Chromosome 9p21 Variants on Cardiovascular Disease. PLoS Med 2011 Oct;8(10):e1001106
• Zbuk K, Xie C, Young R, Heydarpour M, Pare G, Davis A, Miller R, Lanktree M, Saleheen D, Danesh J, Yusuf S, Engert J, Hegele R, Anand SS. BRCA2 Variants and Cardiovascular Disease in a Multi-Ethnic Study. BMC Med Genet 2012 July18;13-56
• Anand S, Dagenais G, Mohan V, Diaz R, Probstfield J, Freeman R, Shaw J, Marshall S, Lanas F, Avezum A, Budaj A, Jung H, Desai D, Bosch J, Yusuf S, Gertstein H. Glucose Levels are Associated with Cardiovascular Disease and Death in an International Cohort of Normal Glycemic and Dysglycemic Men and Women: The EpiDREAM Cohort Study. Eur J Cardiovas Prev Cardiol 2012 Aug;19(4):755-64
• Joseph P, Davis A, Miller R, Hill K, McCarthy H, Banerjee A, Chow C, Mente A, Anand SS. Contextual determinants of health behaviours in an Aboriginal community in Canada: Pilot Project. BMC Public Health 2012 Nov 7;12:952
• Joseph P, Pare G, Anand SS. Exploring Gene-Environment Relationships in Cardiovascular Disease. Can J Cardio 2013 Jan;29(1);37-45
• Anand SS. Vasudevan A, Gupta M, Morrison K, Kurpad A, Teo KK, Srinivasan K, On behalf of the START Cohort Study Investigators. Rationale and Design of South Asian Birth Cohort (START): A Canada-India Collaborative Study BMC Public Health 2013, Jan 28; 13:79
• Kreatsoulas C, Anand SS. Menopausal hormone therapy for the primary prevention of chronic conditions. U.S. Preventative Services Task Force recommendation statement. Pol Arch Med Wewn. 2013:123(3): 112-7.
• Kreatsoulas C, Shannon HS, Giacomini M, Velianou JL, Anand SS. Reconstructing Angina: Cardiac Symptoms Are the Same in Women and Men. JAMA Internal Medicine 2013 Apr. 8:1-2.
• Neylon A, Canniffe C, Anand S, Kreatsoulas c, Blake GJ, Sugrue D, McGorrian D. A global perspective on psychosocial risk factors for cardiovascular disease. Prog Cardiovasc Dis. 2013 May-Jun;55(6): 574-81.
• Kalra S, Mercuri M, Anand SS. Measures of body fat in South Asian Adults. Nutr Diabetes 2013 May 27;3:e69
• Chetty T, Damjanovic S, Gerstein H, Singh N, Yusuf S, Anand SS, Sharma A. Metabolic effects of Telmisartan in subjects with abdomen obesity: a prospective randomized control trial. Blood Pressure, 2013; Jun 3
• Mente A, Meyre D, Lanktree M, Heydarpour M, Davis AD, Miller R, Gerstein H, Hegele RA, Yusuf S, Anand SS. Causal Relationship between Adiponectin and Metabolic Traits: A Mendelian Randomization Study in a Multiethnic Population. PLoS One 2013 June 24;8(6): e66808
• Wahi G, Wilson J, Miller R, Anglin R, McDonald S, Morrison KM, Teo KK, Anand SS. Aboriginal birth cohort (ABC): a prospective cohort study of early life determinants of adiposity and associated risk factors among Aboriginal people in Canada. BMC public health. 2013 Jun 25;13(1):608. [Epub ahead of print]
• Shah BR, Victor JC, Chiu M, Tu JV, Anand SS, Austin PC, Manuel DG, Hux JE. Cardiovascular Complications and Mortality After Diabetes Diagnosis for South Asian and Chinese Patients: A population-based cohort study. Diabetes Care 2013 Sep;36(9):2670-6
• Anand SS, Meyre D, Pare G, Bailey S, Xie C, Zhang X, Montpetit A, Desai D, Bosch J, Mohan V, Diaz R, McQueen M, Cordell H, Keavney B, Yusuf S, Gaudet D, Gerstein H, Engert JC, on behalf of the EpiDREAM Genetics Investigators. Genetic Information and the Prediction of incident Type 2 Diabetes in a High-Risk Multi-Ethnic population: The EpiDREAM Genetic Study. Diabetes Care 2013 Sep;36(9):2836-42
• Oliveira A, Kalra S, Wahi G, McDonald S, Desai D, Wilson J, Jacobs L, Smoke S, Hill P, Hill K, Morrison K, Teo K, Miller R, Anand SS. Maternal and Newborn Health Profile in an Aboriginal Community in Canada. Journal of Obstetrics and Gynaecology
• Wahi G, Anand SS. Race/Ethnicity, obesity and related cardio-metabolic risk factors: A life-course perspective. Curr Cardiovasc Risk Rep (In Press Aug 2013)

Citations for Dr. Anand on PubMed

Research Interests: Environmental and genetic determinants of vascular disease in populations of varying ancestral origin; women and cardiovascular disease.

Associate Chair, Equity and Diversity, Department of Medicine

Director, Population Genomics Program, Department of Clinical Epidemiology and Biostatistics

Canada Research Chair in Ethnic Diversity and Cardiovascular Disease

Heart and Stroke Foundation / Michael G. DeGroote Chair in Population Health Research McMaster University

McMaster University’s Dr. Sonia Anand was only 33 years old when she landed the Eli Lilly Canada-May Cohen Chair in Women’s Health. Although her present research involves the environmental and genetic determinants of vascular and peripheral vascular disease in populations of varying ancestral origin, she is most recognized for her research on women’s health issues, particularly in the area of cardiovascular disease. The care and treatment of women’s cardiovascular disease, unique in its latent and non-specific symptoms, must differ from the standard employed for men to be successful, and Dr. Anand’s research is innovative in making this a priority.

As a Professor with the Department of Medicine and a member of the Leadership Council of the Heart and Stroke Foundation of Canada’s Heart Truth campaign, Dr. Anand has helped give women the tools they need to reduce their risk of cardiovascular disease. Studying the differences associated with each gender’s symptomatic experience of heart disease, Dr. Anand aims to clarify the way in which social factors interact with biological factors to impact cardiovascular health.

Dr. Anand is also the Principal Investigator of two large genetic association studies, including the CIHR/HSFO funded EPiDREAM study of 22,000 people from 21 countries. Complementing this research, Dr. Anand teaches clinical epidemiology courses in methodology and cardiovascular disease at McMaster University with the hope of influencing future generations of doctors to be mindful of women’s health matters.

Selected Publications

• Do R, Xie C, Zhang X, Islam S, Bailey S, Rangarajan S, McQueen M, Diaz R, Lisheng L, Wang X, Yusuf S, Engert J, Anand SS. Dietary Intake Modifies the Effect of Chromosome 9p21 Variants on Cardiovascular Disease. PLoS Med 2011 Oct;8(10):e1001106
• Zbuk K, Xie C, Young R, Heydarpour M, Pare G, Davis A, Miller R, Lanktree M, Saleheen D, Danesh J, Yusuf S, Engert J, Hegele R, Anand SS. BRCA2 Variants and Cardiovascular Disease in a Multi-Ethnic Study. BMC Med Genet 2012 July18;13-56
• Anand S, Dagenais G, Mohan V, Diaz R, Probstfield J, Freeman R, Shaw J, Marshall S, Lanas F, Avezum A, Budaj A, Jung H, Desai D, Bosch J, Yusuf S, Gertstein H. Glucose Levels are Associated with Cardiovascular Disease and Death in an International Cohort of Normal Glycemic and Dysglycemic Men and Women: The EpiDREAM Cohort Study. Eur J Cardiovas Prev Cardiol 2012 Aug;19(4):755-64
• Joseph P, Davis A, Miller R, Hill K, McCarthy H, Banerjee A, Chow C, Mente A, Anand SS. Contextual determinants of health behaviours in an Aboriginal community in Canada: Pilot Project. BMC Public Health 2012 Nov 7;12:952
• Joseph P, Pare G, Anand SS. Exploring Gene-Environment Relationships in Cardiovascular Disease. Can J Cardio 2013 Jan;29(1);37-45
• Anand SS. Vasudevan A, Gupta M, Morrison K, Kurpad A, Teo KK, Srinivasan K, On behalf of the START Cohort Study Investigators. Rationale and Design of South Asian Birth Cohort (START): A Canada-India Collaborative Study BMC Public Health 2013, Jan 28; 13:79
• Kreatsoulas C, Anand SS. Menopausal hormone therapy for the primary prevention of chronic conditions. U.S. Preventative Services Task Force recommendation statement. Pol Arch Med Wewn. 2013:123(3): 112-7.
• Kreatsoulas C, Shannon HS, Giacomini M, Velianou JL, Anand SS. Reconstructing Angina: Cardiac Symptoms Are the Same in Women and Men. JAMA Internal Medicine 2013 Apr. 8:1-2.
• Neylon A, Canniffe C, Anand S, Kreatsoulas c, Blake GJ, Sugrue D, McGorrian D. A global perspective on psychosocial risk factors for cardiovascular disease. Prog Cardiovasc Dis. 2013 May-Jun;55(6): 574-81.
• Kalra S, Mercuri M, Anand SS. Measures of body fat in South Asian Adults. Nutr Diabetes 2013 May 27;3:e69
• Chetty T, Damjanovic S, Gerstein H, Singh N, Yusuf S, Anand SS, Sharma A. Metabolic effects of Telmisartan in subjects with abdomen obesity: a prospective randomized control trial. Blood Pressure, 2013; Jun 3
• Mente A, Meyre D, Lanktree M, Heydarpour M, Davis AD, Miller R, Gerstein H, Hegele RA, Yusuf S, Anand SS. Causal Relationship between Adiponectin and Metabolic Traits: A Mendelian Randomization Study in a Multiethnic Population. PLoS One 2013 June 24;8(6): e66808
• Wahi G, Wilson J, Miller R, Anglin R, McDonald S, Morrison KM, Teo KK, Anand SS. Aboriginal birth cohort (ABC): a prospective cohort study of early life determinants of adiposity and associated risk factors among Aboriginal people in Canada. BMC public health. 2013 Jun 25;13(1):608. [Epub ahead of print]
• Shah BR, Victor JC, Chiu M, Tu JV, Anand SS, Austin PC, Manuel DG, Hux JE. Cardiovascular Complications and Mortality After Diabetes Diagnosis for South Asian and Chinese Patients: A population-based cohort study. Diabetes Care 2013 Sep;36(9):2670-6
• Anand SS, Meyre D, Pare G, Bailey S, Xie C, Zhang X, Montpetit A, Desai D, Bosch J, Mohan V, Diaz R, McQueen M, Cordell H, Keavney B, Yusuf S, Gaudet D, Gerstein H, Engert JC, on behalf of the EpiDREAM Genetics Investigators. Genetic Information and the Prediction of incident Type 2 Diabetes in a High-Risk Multi-Ethnic population: The EpiDREAM Genetic Study. Diabetes Care 2013 Sep;36(9):2836-42
• Oliveira A, Kalra S, Wahi G, McDonald S, Desai D, Wilson J, Jacobs L, Smoke S, Hill P, Hill K, Morrison K, Teo K, Miller R, Anand SS. Maternal and Newborn Health Profile in an Aboriginal Community in Canada. Journal of Obstetrics and Gynaecology
• Wahi G, Anand SS. Race/Ethnicity, obesity and related cardio-metabolic risk factors: A life-course perspective. Curr Cardiovasc Risk Rep (In Press Aug 2013)

Citations for Dr. Anand on PubMed

Research Interests: Environmental and genetic determinants of vascular disease in populations of varying ancestral origin; women and cardiovascular disease.

Leslie Martin completed a Masters in Health Professions Education at Maastricht University. Dr. Martin is currently the Deputy Program Director for the Core Internal Medicine Program, and is involved in the McMaster University Clinical Educator Program as the Assessment Unit Lead. Her research interests include applying qualitative methodology to explore coaching,feedback and learning in postgraduate medical education during the era of competency based medical education (CBME). She has been involved in the design, implementation and now evaluation of the CBME for the Division of General Internal Medicine at McMaster University. Lastly, she has a clinical and research interest in addictions medicine, and is co-chair of the Inpatient Addictions Medicine Service at St. Joseph’s Healthcare Hamilton and Hamilton General Hospital.

Leslie Martin completed a Masters in Health Professions Education at Maastricht University. Dr. Martin is currently the Deputy Program Director for the Core Internal Medicine Program, and is involved in the McMaster University Clinical Educator Program as the Assessment Unit Lead. Her research interests include applying qualitative methodology to explore coaching,feedback and learning in postgraduate medical education during the era of competency based medical education (CBME). She has been involved in the design, implementation and now evaluation of the CBME for the Division of General Internal Medicine at McMaster University. Lastly, she has a clinical and research interest in addictions medicine, and is co-chair of the Inpatient Addictions Medicine Service at St. Joseph’s Healthcare Hamilton and Hamilton General Hospital.