Liat Shenhav, Kelsey Fehr, Myrtha E. Reyna, Charisse Petersen, Darlene L.Y. Dai, et al.

ScienceDirect, CellPress

Microbial colonization programs are structured by breastfeeding and guide healthy respiratory development 10.1016/j.cell.2024.07.022

James D. Douketis, Alex C. Spyropoulos

JAMA Network

Perioperative Management of Patients Taking Direct Oral Anticoagulants 10.1001/jama.2024.12708

Sandra Monteiro, Jonathan Sherbino, Andrew LoGiudice, Mark Lee, et al.

Association for the Study of Medical Education

The influence of viewing time on visual diagnostic accuracy: Less is more 10.1111/medu.15380

Hajar AbuAlrob, George Ioannidis, Susan Jaglal, Andrew Costa, Lauren E. Grifith, et al.

Archives of Osteoporosis

Hip fracture rate and osteoporosis treatment in Ontario: A population-based retrospective cohort study 10.1007/s11657-024-01402-6

David Conen, Michael Ke Wang, Ekaterine Popova, Matthew T. V. Chan, et al.

The Lancet

Effect of colchicine on perioperative atrial fibrillation and myocardial injury after non-cardiac surgery in patients undergoing major thoracic surgery (COP-AF): an international randomised trial 10.1016/s0140-6736(23)01689-6

James C. Fredenburgh, Jeffrey I. Weitz

Journal of Thrombosis and Haemostasis

News at XI: moving beyond factor Xa inhibitors 10.1016/j.jtha.2023.04.021

Deborah A. Marshall, Karen V. MacDonald, Dina Kao, Charles N. Bernstein, Gilaad G. Kaplan, et al.

Therapeutic Advances in Chronic Disease

Patient Preferences for Active Ulcerative Colitis Treatments and Fecal Microbiota Transplantation 10.1177/20406223241239168 

Kamel Mohammedi, Marie Pigeyre, Jackie Bosch, Salim Yusuf, Hertzel C Gerstein

European Heart Journal

Arm and ankle blood pressure indices, and peripheral artery disease, and mortality: a cohort study 10.1093/eurheartj/ehae087

Dongdong Wang, Logan K. Townsend, Geneviève J. DesOrmeaux, Sara M. Frangos, Battsetseg Batchuluun, et al.

Nature

GDF15 promotes weight loss by enhancing energy expenditure in muscle 10.1038/s41586-023-06249-4

LOVIT-COVID Investigators, on behalf of the Canadian Critical Care Trials Group, and the REMAP-CAP Investigators

JAMA Network

Intravenous Vitamin C for Patients Hospitalized With COVID-19: Two Harmonized Randomized Clinical Trials 10.1001/jama.2023.21407

Kerstin de Wit, Fayad Al-Haimus, Yang Hu, Rick Ikesaka, Noel Chan, et al.

Annals of Emergency Medicine

Comparison of YEARS and Adjust-Unlikely D-dimer Testing for Pulmonary Embolism in the Emergency Department 10.1016/j.annemergmed.2022.09.014

Jeff S. Healey, Renato D. Lopes, Christopher B. Granger, Marco Alings, et al.

The New England Journal of Medicine

Apixaban for Stroke Prevention in Subclinical Atrial Fibrillation 10.1056/NEJMoa2310234

Suzanne N. Morin, Sidney Feldman, Larry Funnell, Lora Giangregorio, Sandra Kim, et al.

Canadian Medical Association Journal

Clinical practice guideline for management of osteoporosis and fracture prevention in Canada: 2023 update 10.1503/cmaj.221647

Kefang Lai, Imran Satia, Woo-Jung Song, Gang Wang, Akio Niimi, et al.

The Lancet, Respiratory Medicine

Cough and cough hypersensitivity as treatable traits of asthma 10.1016/S2213-2600(23)00187-X

Chinenye Okpara, George Ioannidis, Lehana Thabane, Jonathan Derrick Adachi, Alexander Rabinovich, et al.

BMC Pilot and Feasibility Studies

The Geras virtual frailty rehabilitation program to build resilience in older adults with frailty during COVID-19: a randomized feasibility trial 10.1186/s40814-023-01346-7

Romina Brignardello-Petersen, George Tomlinson, Ivan Florez, David M. Rind, Derek Chu, et al.

Journal of Clinical Epidemiology

GRADE Concept Article 5: Addressing intransitivity in a network meta-analysis 10.1016/j.jclinepi.2023.06.010

Ruoting Wang, Hertzel C Gerstein, Harriette G C Van Spall, Gregory Y H Lip, Ivan Olier, et al.

European Heart Journal

Relationship Between Remnant Cholesterol and Risk of Heart Failure in Participants with Diabetes Mellitus 10.1093/ehjqcco/qcad030

Gary Liu, Denise B. Catacutan, Khushi Rathod, Kyle Swanson, Wengong Jin, et al.

Nature Chemical Biology

Deep learning-guided discovery of an antibiotic targeting Acinetobacter baumannii 10.1038/s41589-023-01349-8

Eugene Wang, Emilie P. Belley-Côté, Jack Young, Henry He, Haris Saud, et al.

British Journal of Anesthesia

Effect of perioperative benzodiazepine use on intraoperative awareness and postoperative delirium: a systematic review and meta-analysis of randomised controlled trials and observational studies 10.1016/j.bja.2022.12.001

Mahshid Dehghan, Andrew Mente, Sumathy Rangarajan, Viswanathan Mohan, Sumathi Swaminathan, et al.

The American Journal of Clinical Nutrition

Ultra-processed foods and mortality: analysis from the Prospective Urban and Rural Epidemiology study 10.1016/j.ajcnut.2022.10.014

Darryl P. Leong, Ali Zhang, Jessica A. Breznik, Rumi Clare, Angela Huynh, et al.

PLOS ONE

Comparison of three dosing intervals for the primary vaccination of the SARS-CoV-2 mRNA Vaccine (BNT162b2) on magnitude, neutralization capacity and durability of the humoral immune response in health care workers: A prospective cohort study 10.1371/journal.pone.0281673

Jason Weatherald, Ken Kuljit S. Parhar, Zainab Al Duhailib, Derek K. Chu, Anders Granholm, et al.

The BMJ

Efficacy of awake prone positioning in patients with COVID-19 related hypoxemic respiratory failure: systematic review and meta-analysis of randomized trials 10.1136/bmj-2022-071966

Mark Loeb, Amy Bartholomew, Madiha Hashmi, Wadea Tarhuni, Mohamed Hassany, et al.

Annals of Internal Medicine

Medical Masks Versus N95 Respirators for Preventing COVID-19 Among Health Care Workers: A Randomized Trial 10.7326/M22-1966

Shamir R. Mehta, Jia Wang, David A. Wood, John A. Spertus, David J. Cohen, et al.

JAMA Cardiology

Complete Revascularization vs Culprit Lesion-Only Percutaneous Coronary Intervention for Angina-Related Quality of Life in Patients With ST-Segment Elevation Myocardial Infarction: Results From the COMPLETE Randomized Clinical Trial 10.1001/jamacardio.2022.3032

Stuart J. Connolly, Ganesan Karthikeyan, Mpiko Ntsekhe, Abraham Haileamlak, Ahmed El Sayed, et al.

The New England Journal of Medicine

Rivaroxaban in Rheumatic Heart Disease-Associated Atrial Fibrillation 10.1056/NEJMoa2209051

RECOVERY Collaborative Group

The Lancet

Tocilizumab in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial 10.1016/S0140-6736(21)00676-0

RECOVERY Collaborative Group

The Lancet

Tocilizumab in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial 10.1016/S0140-6736(21)00676-0

Philip Joseph, Vellappillil Raman Kutty, Viswanathan Mohan, Rajesh Kumar, et al.

European Heart Journal

Cardiovascular disease, mortality, and their associations with modifiable risk factors in a multi-national South Asia cohort: a PURE substudy 10.1093/eurheartj/ehac249

Marrissa J. McIntosh BSc, Harkiran K. Kooner BSc, Rachel L. Eddy PhD, Samira Jeimy MD, et al.

Science Direct

Asthma Control, Airway Mucus, and 129Xe MRI Ventilation After a Single Benralizumab Dose 10.1016/j.chest.2022.03.003

Jonathan P. Piccini, Valeria Caso, Stuart J. Connolly, Keith A. A. Fox, et al.

Science Direct

Safety of the oral factor XIa inhibitor asundexian compared with apixaban in patients with atrial fibrillation (PACIFIC-AF): a multicentre, randomised, double-blind, double-dummy, dose-finding phase 2 study 10.1016/S0140-6736(22)00456-1

RECOVERY Collaborative Group

Science Direct

Aspirin in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial 10.1016/S0140-6736(21)01825-0

P.J. Devereaux, M.D., Ph.D., Maura Marcucci, M.D., Thomas W. Painter, M.B., Ch.B., David Conen, M.D., M.P.H., et al.

The New England Journal of Medicine

Tranexamic Acid in Patients Undergoing Noncardiac Surgery 10.1056/NEJMoa2201171

Keith A A Fox, Saverio Virdone, Karen S Pieper, Jean-Pierre Bassand, et al.

European Heart Journal

GARFIELD-AF Risk Score For Mortality, Stroke, and Bleeding Within 2 Years in Patients With Atrial Fibrillation 10.1093/ehjqcco/qcab028

Léna Rivard, Leif Friberg, David Conen, Jeffrey S. Healey, et al.

Circulation

Atrial Fibrillation and Dementia: A Report From the AF-SCREEN International Collaboration 10.1161/CIRCULATIONAHA.121.055018

Philippe Bégin, Jeannie Callum,…Donald M. Arnold, et al.

Nature Medicine

Convalescent plasma for hospitalized patients with COVID-19: An open-label, randomized controlled trial 10.1038/s41591-021-01488-2

M. Racey, M. Markle-Reid, D. Fitzpatrick-Lewis, M. U. Ali, H. Gagne, S. Hunter, J. Ploeg, R. Sztramko, L. Harrison, R. Lewis, M. Jovkovic and D. Sherifali.

BioMed Central (BMC) Geriatrics

Fall prevention in community-dwelling adults with mild to moderate cognitive impairment: A systematic review and meta-analysis 10.1186/s12877-021-02641-9

Connie N. Hess, MH Sab, Manesh R.Patel, Rupert M. Bauersachs, Sonia S. Anand, et al.

Journal of the American College of Cardiology

Safety and Effectiveness of Paclitaxel Drug-Coated Devices in Peripheral Artery Revascularization: Insights From VOYAGER PAD 10.1016/j.jacc.2021.08.052

Matt Sibbald, Sandra Monteiro, Jonathan Sherbino, Andrew LoGiudice, Charles Friedman, Geoffrey Norman.

British Medical Association (BMJ) Journals

Should electronic differential diagnosis support be used early or late in the diagnostic process? A multicentre experimental study of Isabel 10.1136/bmjqs-2021-013493

Kollengode Ramanathan, Kiran Shekar, Ryan Ruiyang Ling, Ryan P. Barbaro, Suei Nee Wong, Chuen Seng Tan, Bram Rochwerg, et al.

Critical Care

Extracorporeal membrane oxygenation for COVID-19: A systematic review and meta-analysis 10.1186/s13054-021-03634-1

P. Joseph, G. Roshandel, P. Gao, P. Pais, E. Lonn, D. Xavier, A. Avezum, J. Zhu, L. Liu, K. Sliwa, H. Gamra, S. Bangdiwala, K. Teo, R. S. Yusuf et al.

Cardiovascular disease

Fixed-dose combination therapies with and without aspirin for primary prevention of cardiovascular disease: an individual participant data meta-analysis 10.1016/S0140-6736(21)01827-4

V. Goel, D. Bulir, E. De Prophetis, M. Jamil, L. Rosella, D. Mertz, C. Regehr, M. Smieja.

COVID-19

COVID-19 international border surveillance at Toronto’s Pearson Airport: A cohort study. 2021 Jul 1 10.1136/bmjopen-2021-050714

H. Gerstein, N. Sattar, J. Rosenstock, C. Ramasundarahettige, R. Pratley, R. Lopes, C. Lam, N. Khurmi, L. Heenan, S. Del Prato, L. Dyal, K. Branch.

Diabetes

Cardiovascular and Renal Outcomes with Efpeglenatide in Type 2 Diabetes. 2021 Jun 28 10.1056/NEJMoa2108269

T. O’Shea, C. Bodkin, V. Mokashi, K. Beal, J. Wiwcharuk, R. Lennox, D. Guenter, M. Smieja, D. Bulir, S. Chong.

Clin Infect Dis

Pandemic Planning in Homeless Shelters: A Pilot Study of a Coronavirus Disease 2019 (COVID-19) Testing and Support Program to Mitigate the Risk of COVID-19 Outbreaks in Congregate Settings. 2021 May 4. 10.1093/cid/ciaa743 

K. Xu, K. de Wit, C. Kearon, S. Parpia

Journal of Thrombosis and Haemostasis

A simplified decision rule to rule out deep vein thrombosis using clinical assessment and D-dimer. Journal of Thrombosis and Haemostasis. 2021 Apr 8. 10.1111/jth.15337.

P. Roshanov, D. Sessler, MW Walsh, L. Thabane, PJ Devereaux, et al.

The Canadian Journal of Cardiology (CJC)

Predicting myocardial injury and other cardiac complications after elective noncardiac surgery with the Revised Cardiac Risk Index: The VISION study. The Canadian Journal of Cardiology (CJC). 2021 Mar 23:S0828-282X(21)00164-1. 10.1016/j.cjca.2021.03.015.

I. Nazy, S. Jevtic, J. Moore, A. Huynh, J. Smith, J. Kelton and D. Arnold.

Journal of Thrombosis and Haemostasis

Platelet-activating immune complexes identified in critically ill COVID-19 patients suspected of heparin-induced thrombocytopenia. Journal of Thrombosis and Haemostasis. 2021 Feb 27. doi: 10.1111/jth.15283.

M. Wang, Z. Chen, M. Wong, L. Thabane, L. Mbuagbaw, D. Siegal, G. Le Gal and  A. Holbrook.

Thrombosis Research

Are the correct outcomes being measured in studies of oral anticoagulants? A systematic survey. Thrombosis Research. 2021 Feb 18;201:30-49. doi: 10.1016/j.thromres.2021.02.016

H. Neighbour, S. Monteiro, M. Lee, Y. Wu, A. Levinson, J. Sherbino

Journal of General Internal Medicine

Effect of Gender on Feedback Associated with a Direct Clinical Observation Tool Used during Clerkship at McMaster University. Journal of General Internal Medicine. 2021 Jan 27. 10.1007/s11606-020-06399-5.

S. Yusuf, P. Joseph, A. Dans, P. Gao, K. Teo, D. Xavier, P. López-Jaramillo, K. Yusoff, A. Santoso, the International Polycap Study 3 Investigators, et al.

The New England Journal of Medicine

Polypill with or without Aspirin in Persons without Cardiovascular Disease.  2021 Jan 21;384(3):216-228. 10.1056/NEJMoa2028220.

P. Hewston, CC Kennedy, S. Borhan, D. Merom, P. Santaguida, G. Ioannidis, S. Marr, N. Santesso, L. Thabane, S. Bray, A. Papaioannou.

Age Ageing

Effects of dance on cognitive function in older adults: a systematic review and meta-analysis. 2020 Dec 19. 10.1093/ageing/afaa270

W. Alhazzani, D. Cook, G. Guyatt, et al.

Intensive Care Med

Efficacy and safety of gastrointestinal bleeding prophylaxis in critically ill patients: An updated systematic review and network meta-analysis of randomized trials. 2020 Nov;46(11) 10.1007/s00134-020-06209-w

M. Jeyanathan, S. Afkhami, F. Smaill, MS Miller, BD Lichty, Z. Xing.

Nature Reviews Immunology

Immunological considerations for COVID-19 vaccine strategies. 2020 Oct;20(10): 615-632.10.1038/s41577-020-00434-6

M. Sharma , RG Hart, JW Eikelboom, EM Lonn, S. Yusuf, et al.

Stroke

Rivaroxaban for Prevention of Covert Brain Infarcts and Cognitive Decline: The COMPASS MRI Substudy. Oct;51(10):2901-2909. 10.1161/STROKEAHA.120.029762

CM Clase, M. Joseph, MB Dolovich, et al.

Annals of Internal Medicine

Cloth Masks May Prevent Transmission of COVID-19: An Evidence-Based, Risk-Based Approach. 2020 Sep 15;173(6):489-491. 10.7326/M20-2567

G. Pare, M. Sharma, A. Shoamanesh, et al.

Stroke

High-Sensitivity Cardiac Troponin T for Risk Stratification in Patients With Embolic Stroke of Undetermined Source. 2020 Aug;51(8):2386-2394. 10.1161/STROKEAHA.120.029628

D. Arnold, N. Heddle, E. Jamula, W. Lim, J. Kelton, et al.

The Lancet Haematology

Perioperative oral eltrombopag versus intravenous immunoglobulin in patients with immune thrombocytopenia: A non-inferiority, multicentre, randomised trial. 2020 Sep;7(9):e640-e648. 10.1016/s2352-3026(20)30227-1

M. Zworth, C. Saleh, I. Ball, G. Kalles, S. Oczkowski et al.

BMJ Open

Provision of Medical Assistance in Dying: A Scoping Review. 2020 Jul 8;10(7):e036054. 10.1136/bmjopen-2019-036054

S. Mithoowani, A. Cervi, N. Shah, E. Sirotich, I. Nazy, D. Arnold, et al.

Journal of Thrombosis and Haemostasis

Management of Major Bleeds in Patients With Immune Thrombocytopenia. 2020 Jul;18(7):1783-1790. https://doi.org/10.1111/jth.14809/

M. Mukherjee, A. Bhalla, J. Cherukat, H. Al-Hayyan, A. Ayoub, P. Nair, et al.

European Respiratory Journal

Sub-optimal Treatment Response to anti-IL-5 Monoclonal Antibodies in Severe Eosinophilic Asthmatics With Airway Autoimmune Phenomena. European Respiratory Journal. 2020 May 22;2000117. 10.1183/13993003.00117-2020

S. Anand, K. Schulze, K. Teo, S. Yusuf.

Stroke

Reduced Cognitive Assessment Scores Among Individuals With Magnetic Resonance Imaging-Detected Vascular Brain Injury. Stroke. 2020 Apr;51(4):1158-1165. 10.1161/strokeaha.119.028179.

I. Walker, et al.

Lancet Hematology

Addition of anti-thymocyte globulin to standard graft-versus-host disease prophylaxis versus standard treatment alone in patients with haematological malignancies undergoing transplantation from unrelated donors: final analysis of a randomised, open-label, multicentre, phase 3 trial. Lancet Hematology. 2020 Feb;(7)2:e100-e111. 10.1016/s2352-3026(19)30220-0.

M. Pigeyre, S. Yusuf, H. Gerstein, G. Paré, et al.

Diabetes Care

ACE and Type 2 Diabetes Risk: A Mendelian Randomization Study. Diabetes Care. 2020 Feb 4. pii: dc191973. 10.2337/dc19-1973.

G. Steinberg, et al.

Nature Reviews Drug Discovery

AMP-activated protein kinase: the current landscape for drug development. Nature Reviews Drug Discovery. 2019;18(7):527-551. 10.1038/s41573-019-0019-2.

C. Kearon, K. de Wit, S. Schulman, F. Spencer, S. Bates, et al.

The New England Journal of Medicine

Diagnosis of Pulmonary Embolism with D-Dimer Adjusted to Clinical Probability. N Engl J Med. 2019 Nov 28;381(22):2125-34. 10.1056/NEJMoa1909159

A. Patel, F. Borges, G. Guyatt, W. Szczeklik, A. Garg, M. Walsh, S. Yusuf, PJ Devereaux, et al.

Annals of Internal Medicine

Preoperative N-Terminal Pro-B Type Natriuretic Peptide and Cardiovascular Events After Noncardiac Surgery. 2020 Jan 21;172(2):96-104. 10.7326/m19-2501.