Research within the Division of Nephrology at McMaster University spans the entire spectrum, from basic science research through clinical trials and population-level research. Whether in the laboratory or in the clinic, the overarching focus is to reduce the risk and burden of kidney disease and its complications. Centered at the Hamilton Centre for Kidney Research, basic science research focuses on the underlying mechanisms of progressive kidney disease, vascular dysfunction in hypertension, and vascular calcification associated with chronic kidney disease. Clinical research, at St. Joseph’s Healthcare Hamilton and with the Population Health Research Institute includes clinical trials, epidemiology, and genetic studies of chronic kidney disease, transplantation, glomerulonephritis, vasculitis, cardiovascular disease, and symptoms of kidney disease.