Research Interests: Clinical research in chronic kidney disease care, Provincial Medical Lead for Multi-care Kidney Clinics and Provincial Medical Lead for First Nations, Inuit, Métis and Urban Indigenous Kidney Health at Ontario Renal Network (Ontario Health)

Research Interests: Clinical research in chronic kidney disease care, Provincial Medical Lead for Multi-care Kidney Clinics and Provincial Medical Lead for First Nations, Inuit, Métis and Urban Indigenous Kidney Health at Ontario Renal Network (Ontario Health)

Dr Clase is a nephrologist and epidemiologist.  She is medical lead for the kidney transitional program, providing continuity of care to adolescents transitioning from pediatric to adult care. In the pandemic, she joined McMaster’s Centre of Excellence in Protective Equipment and Materials where she works on community education around cloth masks, and developing better cloth masks.

Research Interests: Advanced chronic kidney disease; potassium; diet; bleeding, thrombosis and anticoagulation; cloth masks.

Dr Clase is a nephrologist and epidemiologist.  She is medical lead for the kidney transitional program, providing continuity of care to adolescents transitioning from pediatric to adult care. In the pandemic, she joined McMaster’s Centre of Excellence in Protective Equipment and Materials where she works on community education around cloth masks, and developing better cloth masks.

Research Interests: Advanced chronic kidney disease; potassium; diet; bleeding, thrombosis and anticoagulation; cloth masks.

Education and Professional Standing

• MSc Health Research Methodology, McMaster University 2007
• Clinician Investigator, RCPSC Certified, McMaster University 2007
• Fellowship RCPSC, Nephrology 2004
• Fellowship RCPSC, Internal Medicine 2003
• MD, McMaster University 1999
• BSc Pharmacy, St. John’s University 1992

Research Interests

• Volume assessment in dialysis patients
• Nocturnal hemodialysis
• Case based learning in postgraduate medical education

Selected Publications

1. Gangji AS, El-Helal B, Brimble S, Churchill DN, Margetts PJ. Association between N Terminal Propeptide B-Type Natriuretic Peptide and Markers of Hypervolemia. Perit Dial Int. 2008 May:28(3):308-11.
2. Gangji AS, Cukierman T, Gerstein HC, Goldsmith CH, Clase CM. A Systematic Review and Meta-analysis of Hypoglycemia and Cardiovascular Events: A Comparison of Glyburide with Other Secretagogues and with Insulin. Diabetes Care. 2007 Feb:30(2):389-94.
3. Gangji AS, Sohal A, Treleaven D, Crowther M. Bleeding in Patients with Renal Insufficiency: A Practical Guide to Clinical Management. Thromb Res. 2006:118(3):423-8.
4. Sohal AS, Gangji AS, Crowther MA, Treleaven D. Uremic Bleeding: Pathophysiology and Clinical Risk Factors. Thromb Res. 2006:118(3):417-22.
5. Chang CY, Gangji AS, Chorneyko K, Kapoor A. Urological manifestations of BK polyomavirus in renal transplant recipients. Can J Urol. 2005 Oct:12(5):2829-36.
6. Gangji AS, Windrum R, Gandhi S, Silverman JA, Chan CT: Successful Pregnancy with Nocturnal Hemodialysis. American Journal of Kidney Diseases. 2004 Nov:44(5):912-6.
7. Gangji AS, Rabbat CG, Margetts PJ: Benefit of Continuous Renal Replacement Therapy in Subgroups of Acutely Ill Patients: a Retrospective Analysis. Clinical Nephrology. 2004 Apr; 63(4):267-75.
8. Xenodemetropoulos T, Wasi P, Eva K, Norman G, Gangji AS. Introduction of a Case-Based Learning Cirriculum for PGY-3 Internal Medicine Residents. International Conference on Residency Education 2008. RCPSC 2008
9. Gangji AS, Margetts PJ, Churchill DN, Brimble KS, Wickenden TC, Wilkieson TJ, Bilyk L, Robinson K, Prieur A, Clase CM. Relationship Between Volume Status, Assessed by Bioimpedance and Modality in Prevalent and Incident Dialysis Patients. J Am Soc Nephrol; 18:257A.
10. Gangji AS, El-Helal B, Brimble S, Churchill DN, Margetts PJ: How Good is the Clinical Examination in the Assessment of Volume Status in Peritoneal Dialysis Patients. J Am Soc Nephrol 16: 2005. (Abstract F-P0594).
11. Gangji AS, El-Helal B, Brimble S, Churchill DN, Margetts PJ: Volume Expansion and Peritoneal Inflammation Correlate with Solute Transport in Peritoneal Dialysis Patients. J Am Soc Nephrol 16: 2005. (Abstract F-P0593).

Research Interests: Volume assessment in dialysis patients, Nocturnal hemodialysis, Case based learning in postgraduate medical education

Education and Professional Standing

• MSc Health Research Methodology, McMaster University 2007
• Clinician Investigator, RCPSC Certified, McMaster University 2007
• Fellowship RCPSC, Nephrology 2004
• Fellowship RCPSC, Internal Medicine 2003
• MD, McMaster University 1999
• BSc Pharmacy, St. John’s University 1992

Research Interests

• Volume assessment in dialysis patients
• Nocturnal hemodialysis
• Case based learning in postgraduate medical education

Selected Publications

1. Gangji AS, El-Helal B, Brimble S, Churchill DN, Margetts PJ. Association between N Terminal Propeptide B-Type Natriuretic Peptide and Markers of Hypervolemia. Perit Dial Int. 2008 May:28(3):308-11.
2. Gangji AS, Cukierman T, Gerstein HC, Goldsmith CH, Clase CM. A Systematic Review and Meta-analysis of Hypoglycemia and Cardiovascular Events: A Comparison of Glyburide with Other Secretagogues and with Insulin. Diabetes Care. 2007 Feb:30(2):389-94.
3. Gangji AS, Sohal A, Treleaven D, Crowther M. Bleeding in Patients with Renal Insufficiency: A Practical Guide to Clinical Management. Thromb Res. 2006:118(3):423-8.
4. Sohal AS, Gangji AS, Crowther MA, Treleaven D. Uremic Bleeding: Pathophysiology and Clinical Risk Factors. Thromb Res. 2006:118(3):417-22.
5. Chang CY, Gangji AS, Chorneyko K, Kapoor A. Urological manifestations of BK polyomavirus in renal transplant recipients. Can J Urol. 2005 Oct:12(5):2829-36.
6. Gangji AS, Windrum R, Gandhi S, Silverman JA, Chan CT: Successful Pregnancy with Nocturnal Hemodialysis. American Journal of Kidney Diseases. 2004 Nov:44(5):912-6.
7. Gangji AS, Rabbat CG, Margetts PJ: Benefit of Continuous Renal Replacement Therapy in Subgroups of Acutely Ill Patients: a Retrospective Analysis. Clinical Nephrology. 2004 Apr; 63(4):267-75.
8. Xenodemetropoulos T, Wasi P, Eva K, Norman G, Gangji AS. Introduction of a Case-Based Learning Cirriculum for PGY-3 Internal Medicine Residents. International Conference on Residency Education 2008. RCPSC 2008
9. Gangji AS, Margetts PJ, Churchill DN, Brimble KS, Wickenden TC, Wilkieson TJ, Bilyk L, Robinson K, Prieur A, Clase CM. Relationship Between Volume Status, Assessed by Bioimpedance and Modality in Prevalent and Incident Dialysis Patients. J Am Soc Nephrol; 18:257A.
10. Gangji AS, El-Helal B, Brimble S, Churchill DN, Margetts PJ: How Good is the Clinical Examination in the Assessment of Volume Status in Peritoneal Dialysis Patients. J Am Soc Nephrol 16: 2005. (Abstract F-P0594).
11. Gangji AS, El-Helal B, Brimble S, Churchill DN, Margetts PJ: Volume Expansion and Peritoneal Inflammation Correlate with Solute Transport in Peritoneal Dialysis Patients. J Am Soc Nephrol 16: 2005. (Abstract F-P0593).

Research Interests: Volume assessment in dialysis patients, Nocturnal hemodialysis, Case based learning in postgraduate medical education

Research Interests: Molecular mechanisms of fibrosis in diabetic and hypertensive kidney disease

Research Interests: Molecular mechanisms of fibrosis in diabetic and hypertensive kidney disease

Dr. Margetts has an active basic science laboratory with research interests in the mechanisms of fibrosis. We specifically look at peritoneal fibrosis and the implication in clinical peritoneal dialysis. We are interested in the epithelial mesenchymal transition and angiogenesis. We use adenovirus to transfer genes to the peritoneal cavity and then study the fibrogenic response. Most recently, we have made some interesting observations about hypoxia and the role in fibrosis, and have developed an interest in T-cells and the interaction with fibrosis.

We also have an active research program in adenovirus based gene transfer to the kidney and progressive renal disease. This is a new area of research for our group, but we already have made some interesting advances. We also have developed a novel adenovirus based gene transfer vector – the gutless, or helper dependent adenovirus.

The lab includes a senior technician, post doc, 3 graduate students, and a project student. As part of the Hamilton Centre for Kidney Research, we have access to advanced basic science technologies and a full level 2 biohazard facility.

Research Interests: Mechanisms of fibrosis; Peritoneal fibrosis and the implication in clinical peritoneal dialysis; epithelial mesenchymal transition and angiogenesis; hypoxia and the role in fibrosis; T-cells and the interaction with fibrosis; adenovirus based gene transfer to the kidney and progressive renal disease.

Dr. Margetts has an active basic science laboratory with research interests in the mechanisms of fibrosis. We specifically look at peritoneal fibrosis and the implication in clinical peritoneal dialysis. We are interested in the epithelial mesenchymal transition and angiogenesis. We use adenovirus to transfer genes to the peritoneal cavity and then study the fibrogenic response. Most recently, we have made some interesting observations about hypoxia and the role in fibrosis, and have developed an interest in T-cells and the interaction with fibrosis.

We also have an active research program in adenovirus based gene transfer to the kidney and progressive renal disease. This is a new area of research for our group, but we already have made some interesting advances. We also have developed a novel adenovirus based gene transfer vector – the gutless, or helper dependent adenovirus.

The lab includes a senior technician, post doc, 3 graduate students, and a project student. As part of the Hamilton Centre for Kidney Research, we have access to advanced basic science technologies and a full level 2 biohazard facility.

Research Interests: Mechanisms of fibrosis; Peritoneal fibrosis and the implication in clinical peritoneal dialysis; epithelial mesenchymal transition and angiogenesis; hypoxia and the role in fibrosis; T-cells and the interaction with fibrosis; adenovirus based gene transfer to the kidney and progressive renal disease.

Research Interests: Large databases analyses; clinical outcomes in maintenance hemodialysis

Research Interests: Large databases analyses; clinical outcomes in maintenance hemodialysis

Research Interests: Clinical investigation in chronic kidney disease and dialysis.

Research Interests: Clinical investigation in chronic kidney disease and dialysis.

Research Interests: Living kidney donor health, allocation of deceased donor organs, optimal utilization of deceased donor organs

Research Interests: Living kidney donor health, allocation of deceased donor organs, optimal utilization of deceased donor organs

Research Interests: epidemiology of glomerulonephritis and vasculitis, and outcomes of kidney failure; clinical trials in glomerulonephritis, vasculitis, cardiovascular disease, and symptoms of kidney failure; clinical trial methodology

Research Interests: epidemiology of glomerulonephritis and vasculitis, and outcomes of kidney failure; clinical trials in glomerulonephritis, vasculitis, cardiovascular disease, and symptoms of kidney failure; clinical trial methodology