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Faculty of Health Sciences

Department of Medicine

A potential new way to slow the progression of chronic kidney disease

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Investigators at the Hamilton Center for Kidney Research have found an increase in the protein Activin A in various laboratory models of chronic kidney disease. Inhibiting the action of activins decreased kidney scarring and slowed the progression of chronic kidney disease. Studies will now aim to better understand how Activin A contributes to kidney disease, and to test whether this is also a safe and effective way of slowing progression in people with chronic kidney disease.

References

Kidney Int. 2019 Nov;96(5):1134-1149. https://doi.org/10.1016/j.kint.2019.05.032. Epub 2019 Jun 17. PMID: 31492508
Antioxid Redox Signal. 2019 Sep 10;31(8):551-571. https://www.liebertpub.com/doi/10.1089/ars.2018.7684. Epub 2019 Jul 3. PMID: 31184201

 Nephrology Research